Disease: Hereditary Breast and Ovarian Cancer Syndrome
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
RAD51D O75771 RAD51 paralog D 1.1E-09 0.674 0.385
RAD51C O43502 RAD51 paralog C 6.2E-14 0.533 0.692
RAD51B O15315 RAD51 paralog B 2.1E-15 0.556 0.769
RAD51 Q06609 RAD51 recombinase 2.7E-02 0.447 0.846
RAD50 Q92878 RAD50 double strand break repair protein 3.4E-27 0.556 0.808
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MRE11 P49959 MRE11 homolog, double strand break repair nuclease 1.3E-12 0.527 0.808
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
KRT88P keratin 88 pseudogene 0.705 0.385
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
HSD17B1 P14061 hydroxysteroid 17-beta dehydrogenase 1 Enzyme 1.3E-04 0.610 0.615
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
FANCA O15360 FA complementation group A 1.6E-68 0.505 0.731
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
EMSY Q7Z589 EMSY transcriptional repressor, BRCA2 interacting 1.00 0.628 0.423
COL11A2 P13942 collagen type XI alpha 2 chain 0.70 0.435 0.846